Apicomplexan AMA1 in Host Cell Invasion: A Model at the Junction?
نویسندگان
چکیده
منابع مشابه
Host Cell Invasion by Apicomplexan Parasites: The Junction Conundrum
1 Institut Pasteur, Malaria Biology and Genetics Unit, Department of Parasitology and Mycology, Paris, France, 2 Institut Cochin, Laboratory Barriers and Pathogens, INSERM U-1016, CNRS UMR-8104, University of Paris Descartes, Paris, France, 3 Institute of Infection, Immunity and Inflammation, Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, ...
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Obligate intracellular Apicomplexa parasites share a unique invasion mechanism involving a tight interaction between the host cell and the parasite surfaces called the moving junction (MJ). The MJ, which is the anchoring structure for the invasion process, is formed by secretion of a macromolecular complex (RON2/4/5/8), derived from secretory organelles called rhoptries, into the host cell memb...
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UNLABELLED Apical membrane antigen 1 (AMA1) is a receptor protein on the surface of Toxoplasma gondii that plays a critical role in host cell invasion. The ligand to which T gondii AMA1 (TgAMA1) binds, TgRON2, is secreted into the host cell membrane by the parasite during the early stages of invasion. The TgAMA1-TgRON2 complex forms the core of the "moving junction," a ring-shaped zone of tight...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2011
ISSN: 1931-3128
DOI: 10.1016/j.chom.2011.11.006